安普克
生物利用度
肠道菌群
PI3K/AKT/mTOR通路
代谢综合征
过剩4
微生物群
代谢途径
生物
化学
生物化学
药理学
生物信息学
信号转导
内分泌学
胰岛素抵抗
糖尿病
磷酸化
新陈代谢
蛋白激酶A
作者
Meng Shi,Yuting Lu,Junling Wu,Zhibing Zheng,Chenghao Lv,Jian‐Hui Ye,Si Qin,Chaoxi Zeng
摘要
In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS). Theaflavins (TFs) are a polyphenol hydroxyl substance with the structure of diphenol ketone, and they have the potential to prevent and treat a wide range of MetS. However, the stability and bioavailability of TFs are poor. TFs have the marvelous ability to alleviate MetS through antiobesity and lipid-lowering (AMPK-FoxO3A-MnSOD, PPAR, AMPK, PI3K/Akt), hypoglycemic (IRS-1/Akt/GLUT4, Ca2+/CaMKK2-AMPK, SGLT1), and uric-acid-lowering (XO, GLUT9, OAT) effects, and the modulation of the gut microbiota (increasing beneficial gut microbiota such as Akkermansia and Prevotella). This paper summarizes and updates the bioavailability of TFs, and the available signaling pathways and molecular evidence on the functionalities of TFs against metabolic abnormalities in vitro and in vivo, representing a promising opportunity to prevent MetS in the future with the utilization of TFs.
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