Intracellular Condensates of Oligopeptide for Targeting Lysosome and Addressing Multiple Drug Resistance of Cancer (Adv. Mater. 1/2022)

Artificial Biomolecular Condensates In article number 2104704, Huaimin Wang and co-workers report a general approach for constructing artificial biomolecular condensates of oligopeptide in living cells. The rationally designed aromatic-capped peptides can reversibly form a nanofibrous hydrogel with a change of the conformation and morphologies in the lysosome. The formed condensates undergo swelling in the lysosome, leading to lysosomal membrane permeabilization and re-direction of therapeutic drugs to the target.