Aptamer HB5 modified terahertz metasurface biosensor used for specific detection of HER2

生物传感器 适体 材料科学 基质(水族馆) 生物分子 太赫兹辐射 光电子学 纳米技术 海洋学 遗传学 地质学 生物
作者
Qingpeng Zeng,Wentao Liu,Shangjun Lin,Zhencheng Chen,Lizeng Zeng,Fangrong Hu
出处
期刊:Sensors and Actuators B-chemical [Elsevier BV]
卷期号:355: 131337-131337 被引量:49
标识
DOI:10.1016/j.snb.2021.131337
摘要

In the work, an aptamer modified terahertz (THz) metasurface (MS) biosensor is proposed to specifically detect the human epidermal growth factor receptor 2 (HER2) which is a typical label of breast cancer. The biosensor is an array structure consisting of two metal split-ring-resonators (SRRs) in a unit cell. Compared with the conventional SRRs directly fabricated on high resistance silicon substrate, 500-nm-thick silicon dioxide spacer is introduced between the metal SRRs and the silicon substrate of the proposed biosensor to obtain high Quality (Q). Simulation results show that the biosensor has two resonant frequencies, and the sensitivity of the high frequency resonant frequency reaches to 108 GHz/RIU (Refractive Index Unit). The biosensor is fabricated by using a surface micromachining process and characterized by a THz time domain spectroscopy (TDS) system. To specifically detect the HER2, the aptamer-HB5 (APT-HB5) with a concentration of 5 μmol/mL is used to modify the surface of the biosensor. The experiment result show that the aptamer modified biosensor has higher detection sensitivity, and the limit-of-detection (LOD) reaches to 0.1 ng/mL. Most importantly, it is more sensitive to the antigen HER2 than the other markers of the CEA and the AFP. The proposed method can be extended to design other aptamer biosensors for specifically detecting the biomarkers of other cancers. This study paves a new way for specific detection of cancer biomarkers and other biomolecules, which is of great significance for early detection of cancer, especially for the breast cancer.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
寄语明月发布了新的文献求助30
4秒前
17377758395完成签到,获得积分10
4秒前
牛马发布了新的文献求助10
6秒前
6秒前
7秒前
7秒前
酷波er应助论文侠采纳,获得10
7秒前
8秒前
郭小宝发布了新的文献求助10
10秒前
丘比特应助letter采纳,获得10
10秒前
10秒前
12秒前
坚强枫发布了新的文献求助10
14秒前
14秒前
陶醉延恶发布了新的文献求助10
14秒前
寄语明月完成签到,获得积分10
14秒前
CipherSage应助ZWGS采纳,获得30
16秒前
17秒前
18秒前
张雷应助Quinna采纳,获得20
18秒前
19秒前
Cloud发布了新的文献求助10
19秒前
19秒前
传奇3应助小胖采纳,获得10
20秒前
陶醉延恶完成签到,获得积分20
22秒前
budingman发布了新的文献求助20
23秒前
Peng应助毛豆爸爸采纳,获得10
24秒前
letter发布了新的文献求助10
25秒前
zwy109发布了新的文献求助10
25秒前
25秒前
细辛发布了新的文献求助10
25秒前
26秒前
小刺猬发布了新的文献求助10
28秒前
31秒前
32秒前
小小应助文件撤销了驳回
32秒前
小胖完成签到,获得积分10
32秒前
李健应助22222采纳,获得10
32秒前
脑洞疼应助陶醉延恶采纳,获得10
33秒前
鳗鱼思真完成签到,获得积分20
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988997
求助须知:如何正确求助?哪些是违规求助? 3531351
关于积分的说明 11253520
捐赠科研通 3269928
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882063
科研通“疑难数据库(出版商)”最低求助积分说明 809068