亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Association of Genetically Predicted BCAA Levels with Muscle Fiber Size in Athletes Consuming Protein

单核苷酸多态性 内科学 生物 内分泌学 等位基因 骨骼肌 代谢物 医学 遗传学 基因型 基因
作者
Elliott Hall,Ekaterina Semenova,Э.А. Бондарева,Liliya B Andryushchenko,Andrey K. Larin,Paweł Cięszczyk,Edward V. Generozov,Ildus I. Ahmetov
出处
期刊:Genes [Multidisciplinary Digital Publishing Institute]
卷期号:13 (3): 397-397 被引量:4
标识
DOI:10.3390/genes13030397
摘要

Branched-chain amino acid (BCAA) levels are associated with skeletal muscle cross-sectional area (CSA). Serum BCAA levels are enhanced by whey protein supplementation (WPS), and evidence in clinical populations suggests an association of single nucleotide polymorphisms (SNPs) with BCAA metabolite levels. It is not known whether the same SNPs are associated with the ability to catabolise BCAAs from exogenous sources, such as WPS. The present study investigated whether possessing a higher number of alleles associated with increased BCAA metabolites correlates with muscle fiber CSA of m. vastus lateralis in physically active participants, and whether any relationship is enhanced by WPS. Endurance-trained participants (n = 75) were grouped by self-reported habitual WPS consumption and genotyped for five SNPs (PPM1K rs1440580, APOA5 rs2072560, CBLN1 rs1420601, DDX19B rs12325419, and TRMT61A rs58101275). Body mass, BMI, and fat percentage were significantly lower and muscle mass higher in the WPS group compared to Non-WPS. The number of BCAA-increasing alleles was correlated with fiber CSA in the WPS group (r = 0.75, p < 0.0001) and was stronger for fast-twitch fibers (p = 0.001) than slow-twitch fibers (p = 0.048). Similar results remained when corrected for multiple covariates (age, physical activity, and meat and dairy intake). No correlation was found in the Non-WPS group. This study presents novel evidence of a positive relationship between BCAA-increasing alleles and muscle fiber CSA in athletes habitually consuming WPS. We suggest that a high number of BCAA-increasing alleles improves the efficiency of WPS by stimulation of muscle protein synthesis, and contributes to greater fiber CSA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
梨子茶发布了新的文献求助30
13秒前
mczhu完成签到,获得积分10
13秒前
聪慧芷巧完成签到 ,获得积分10
24秒前
qqJing完成签到,获得积分10
34秒前
deallyxyz应助草木采纳,获得10
34秒前
47秒前
47秒前
常有李完成签到,获得积分10
1分钟前
1分钟前
默默孱完成签到 ,获得积分10
1分钟前
JamesPei应助汎影采纳,获得10
1分钟前
1分钟前
Lucas应助汎影采纳,获得10
1分钟前
wwe完成签到,获得积分10
1分钟前
爆米花应助汎影采纳,获得10
1分钟前
完美世界应助汎影采纳,获得10
2分钟前
2分钟前
隐形曼青应助汎影采纳,获得10
2分钟前
2分钟前
乐乐应助汎影采纳,获得10
2分钟前
ding应助汎影采纳,获得10
2分钟前
2分钟前
烟花应助汎影采纳,获得10
3分钟前
3分钟前
大个应助汎影采纳,获得10
3分钟前
梨子茶发布了新的文献求助10
3分钟前
领导范儿应助科研通管家采纳,获得10
3分钟前
汎影完成签到,获得积分10
3分钟前
笨笨完成签到 ,获得积分10
3分钟前
3分钟前
Betty发布了新的文献求助10
3分钟前
3分钟前
科研佟完成签到 ,获得积分10
4分钟前
Setlla完成签到 ,获得积分10
4分钟前
4分钟前
灵筠完成签到,获得积分10
4分钟前
清爽乐菱完成签到,获得积分10
5分钟前
小神仙完成签到 ,获得积分10
5分钟前
斯文败类应助科研通管家采纳,获得10
5分钟前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968504
求助须知:如何正确求助?哪些是违规求助? 3513278
关于积分的说明 11167247
捐赠科研通 3248678
什么是DOI,文献DOI怎么找? 1794409
邀请新用户注册赠送积分活动 875030
科研通“疑难数据库(出版商)”最低求助积分说明 804638