FADS1 overexpression promotes fatty acid synthesis and triacylglycerol accumulation via inhibiting the AMPK/SREBP1 pathway in goat mammary epithelial cells

During lactation, FADS1 is up-regulated, then inhibits the phosphorylation of AMPK. The downregulation of p-AMPK promotes SREBP1 nuclear translocation, and induces SREBP1 target gene FASN and ACC expression in GMEC, leading to increased lipogenesis.