Non-Pharmacological Self-Management Strategies for Chemotherapy-Induced Peripheral Neuropathy in People with Advanced Cancer: A Systematic Review and Meta-Analysis

医学 荟萃分析 随机对照试验 化疗所致周围神经病变 内科学 物理疗法 心理干预 严格标准化平均差 不利影响 科克伦图书馆 置信区间 周围神经病变 精神科 糖尿病 内分泌学
作者
Megan Crichton,Patsy Yates,Oluwaseyifunmi Andi Agbejule,A. Spooner,Raymond J. Chan,Nicolas H. Hart
出处
期刊:Nutrients [Multidisciplinary Digital Publishing Institute]
卷期号:14 (12): 2403-2403 被引量:9
标识
DOI:10.3390/nu14122403
摘要

Non-pharmacological self-management interventions for chemotherapy-induced peripheral neurotherapy (CIPN) are of clinical interest; however, no systematic review has synthesized the evidence for their use in people with advanced cancer. Five databases were searched from inception to February 2022 for randomized controlled trials assessing the effect of non-pharmacological self-management interventions in people with advanced cancer on the incidence and severity of CIPN symptoms and related outcomes compared to any control condition. Data were pooled with meta-analysis. Quality of evidence was appraised using the Revised Cochrane Risk of Bias Tool for Randomized Trials (RoB2), with data synthesized narratively. Grading of Recommendations, Assessment, Development and Evaluations (GRADE) was applied to assess the certainty of the evidence. Thirteen studies were included, which had a high (69%) or unclear (31%) risk of bias. Greatest confidence was found for physical exercise decreasing CIPN severity (SMD: −0.89, 95% CI: −1.37 to −0.41; p = 0.0003; I2 = 0%; n = 2 studies, n = 76 participants; GRADE level: moderate) and increasing physical function (SMD: 0.51, 95% CI: 0.02 to 1.00; p = 0.04; I2 = 42%; n = 3 studies, n = 120; GRADE level: moderate). One study per intervention provided preliminary evidence for the positive effects of glutamine supplementation, an Omega-3 PUFA-enriched drink, and education for symptom self-management via a mobile phone game on CIPN symptoms and related outcomes (GRADE: very low). No serious adverse events were reported. The strongest evidence with the most certainty was found for physical exercise as a safe and viable adjuvant to chemotherapy treatment for the prevention and management of CIPN and related physical function in people with advanced cancer. However, the confidence in the evidence to inform conclusions was mostly very low to moderate. Future well-powered and appropriately designed interventions for clinical trials using validated outcome measures and clearly defined populations and strategies are warranted.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Star完成签到,获得积分10
2秒前
2秒前
柔弱的不二完成签到,获得积分10
3秒前
无心的枫完成签到,获得积分10
5秒前
djdh完成签到 ,获得积分10
5秒前
肖果完成签到 ,获得积分10
8秒前
哭泣笑柳发布了新的文献求助10
9秒前
CipherSage应助长安采纳,获得10
10秒前
飒飒完成签到,获得积分10
11秒前
RONG完成签到 ,获得积分10
11秒前
落落完成签到,获得积分10
12秒前
Yan完成签到 ,获得积分10
13秒前
13秒前
谨慎的凝丝完成签到 ,获得积分10
14秒前
雨洋完成签到,获得积分10
15秒前
chi完成签到 ,获得积分10
16秒前
还单身的湘完成签到,获得积分10
18秒前
fyjlfy完成签到 ,获得积分10
18秒前
深情安青应助Nayvue采纳,获得10
19秒前
研友_Y59785完成签到,获得积分0
19秒前
Xiaoxiao发布了新的文献求助10
20秒前
初初见你完成签到,获得积分10
27秒前
30秒前
思源应助淡淡月饼采纳,获得20
30秒前
dd完成签到 ,获得积分10
31秒前
Nayvue发布了新的文献求助10
35秒前
未来的幻想完成签到,获得积分10
37秒前
Kvolu29完成签到,获得积分10
38秒前
长理物电强完成签到,获得积分10
39秒前
若安在完成签到,获得积分10
40秒前
完美世界应助潘特采纳,获得10
41秒前
拼搏问薇完成签到 ,获得积分10
41秒前
单薄乐珍完成签到 ,获得积分0
44秒前
张静枝完成签到 ,获得积分10
44秒前
六步郎完成签到,获得积分10
44秒前
啊怙纲完成签到 ,获得积分10
46秒前
量子星尘发布了新的文献求助10
48秒前
scott_zip完成签到 ,获得积分10
49秒前
gxl完成签到,获得积分0
53秒前
xxx完成签到 ,获得积分10
56秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022