脱氧核酶
内体
基因沉默
光动力疗法
化学
光子上转换
纳米技术
纳米载体
生物物理学
基因
材料科学
发光
药物输送
DNA
光电子学
生物
生物化学
细胞内
有机化学
作者
Yaoxuan Chen,Rupeng Zhao,Lele Li,Yuliang Zhao
出处
期刊:Angewandte Chemie
[Wiley]
日期:2022-06-22
卷期号:61 (34): e202206485-e202206485
被引量:35
标识
DOI:10.1002/anie.202206485
摘要
Despite the enormous potential of DNAzyme for gene therapy, its efficacy is hampered by the limited endosomal escape capability. Here, we develop a near-infrared (NIR) light-controlled DNAzyme delivery platform to achieve enhanced gene-silencing efficacy. The nanoplatform is composed of therapeutic DNAzyme, photosensitizers (PSs) and upconversion nanoparticles (UCNPs) that can convert NIR light to visible light. The system allows NIR light-activatable generation of cytotoxic reactive oxygen species due to the energy transfer from the UCNPs to PSs, which boosts the endosomal escape of DNAzyme for an improved gene-silencing efficacy. We demonstrate that the nanocomposites represent a promising platform to integrate DNAzyme-based gene therapy with NIR light-triggered photodynamic therapy for combinational tumor treatment. This work highlights a robust approach to combat the current limitations of DNAzyme delivery systems.
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