生物矿化
磷灰石
细胞外基质
矿化(土壤科学)
生物物理学
基质(化学分析)
成核
Ⅰ型胶原
体内
矿化组织
纤维
化学
材料科学
化学工程
细胞生物学
矿物学
生物
生物化学
复合材料
内分泌学
生物技术
有机化学
牙本质
氮气
工程类
作者
Yan Wang,Thierry Azaı̈s,Marc Robin,Anne Vallée,Chelsea Catania,Patrick Legriel,Gérard Pehau‐Arnaudet,Florence Babonneau,Marie‐Madeleine Giraud‐Guille,Nadine Nassif
出处
期刊:Nature Materials
[Springer Nature]
日期:2012-06-29
卷期号:11 (8): 724-733
被引量:523
摘要
The involvement of collagen in bone biomineralization is commonly admitted, yet its role remains unclear. Here we show that type I collagen in vitro can initiate and orientate the growth of carbonated apatite mineral in the absence of any other vertebrate extracellular matrix molecules of calcifying tissues. We also show that the collagen matrix influences the structural characteristics on the atomic scale, and controls the size and the three-dimensional distribution of apatite at larger length scales. These results call into question recent consensus in the literature on the need for Ca-rich non-collagenous proteins for collagen mineralization to occur in vivo. Our model is based on a collagen/apatite self-assembly process that combines the ability to mimic the in vivo extracellular fluid with three major features inherent to living bone tissue, that is, high fibrillar density, monodispersed fibrils and long-range hierarchical organization.
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