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Association of Hemodynamic Factors With Intracranial Aneurysm Formation and Rupture

动脉瘤 血流动力学 医学 心脏病学 内科学 放射科
作者
Anil Can,Rose Du
出处
期刊:Neurosurgery [Lippincott Williams & Wilkins]
卷期号:78 (4): 510-520 被引量:122
标识
DOI:10.1227/neu.0000000000001083
摘要

BACKGROUND: Recent evidence suggests a link between the magnitude and distribution of hemodynamic factors and the formation and rupture of intracranial aneurysms. However, there are many conflicting results. OBJECTIVE: To quantify the effect of hemodynamic factors on aneurysm formation and their association with ruptured aneurysms. METHODS: We performed a systematic review and meta-analysis through October 2014. Analysis of the effects of hemodynamic factors on aneurysm formation was performed by pooling the results of studies that compared geometrical models of intracranial aneurysms and “preaneurysm” models where the aneurysm was artificially removed. Furthermore, we calculated pooled standardized mean differences between ruptured and unruptured aneurysms to quantify the association of hemodynamic factors with ruptured aneurysms. Standard PRISMA guidelines were followed. RESULTS: The hemodynamic factors that showed high positive correlations with location of aneurysm formation were high wall shear stress (WSS) and high gradient oscillatory number, with pooled proportions of 78.8% and 85.7%, respectively. Positive correlations were largely seen in bifurcation aneurysms, whereas negative correlations were seen in sidewall aneurysms. Mean and normalized WSS were significantly lower and low shear area significantly higher in ruptured aneurysms. CONCLUSION: Pooled analyses of computational fluid dynamics models suggest that an increase in WSS and gradient oscillatory number may contribute to aneurysm formation, whereas low WSS is associated with ruptured aneurysms. The location of the aneurysm at the bifurcation or sidewall may influence the correlation of these hemodynamic factors. ABBREVIATIONS: AFI, aneurysm formation index CFD, computational fluid dynamics GON, gradient oscillatory number IA, intracranial aneurysm LSA, low shear index OSI, oscillatory shear index SD, standard deviation SMD, standardized mean difference SWSSG, spatial wall shear stress gradient WSS, wall shear stress
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