色胺
酪胺
单胺氧化酶
化学
生物胺
纹状体
单胺氧化酶B
内科学
内分泌学
肾
芳香族L-氨基酸脱羧酶
多巴胺
药理学
生物化学
血清素
生物
酶
医学
受体
出处
期刊:Life Sciences
[Elsevier]
日期:1987-02-01
卷期号:40 (6): 571-575
被引量:9
标识
DOI:10.1016/0024-3205(87)90371-7
摘要
The concentrations of the trace amines, m-tyramine, p-tyramine, phenylethylamine and tryptamine, were measured in the striatum of the brain and in the kidney of adult rats treated with α-monofluoromethyldopa (MFMD), an inhibitor of aromatic amino acid decarboxylase. While MFMD decreased the levels of all four amines in the kidney, only phenylethylamine and tryptamine levels were decreased in the striatum compared to control. Striatal p-tyramine levels were not affected, while striatal m-tyramine levels were increased by MFMD. When the rats were injected with a monoamine oxidase (MAO) inhibitor before MFMD administration, similar changes in striatal and kidney trace amine levels were observed compared to MFMD alone.
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