数量结构-活动关系
欧洲联盟
背景(考古学)
授权
农业
风险评估
立法机关
人类健康
风险分析(工程)
计算机科学
业务
政治学
生物
医学
生态学
环境卫生
计算机安全
经济政策
机器学习
古生物学
法学
作者
Juan José Villaverde,Beatriz Sevilla-Morán,Carmen López‐Goti,José Luis Alonso‐Prados,Pilar Sandín‐España
标识
DOI:10.1016/j.scitotenv.2018.04.033
摘要
The European market for pesticides is currently legislated through the well-developed Regulation (EC) No. 1107/2009. This regulation promotes the competitiveness of European agriculture, recognizing the necessity of safe pesticides for human and animal health and the environment to protect crops against pests, diseases and weeds. In this sense, nanotechnology can provide a tremendous opportunity to achieve a more rational use of pesticides. However, the lack of information regarding nanopesticides and their fate and behavior in the environment and their effects on human and animal health is inhibiting rapid nanopesticide incorporation into European Union agriculture. This review analyzes the recent state of knowledge on nanopesticide risk assessment, highlighting the challenges that need to be overcame to accelerate the arrival of these new tools for plant protection to European agricultural professionals. Novel nano-Quantitative Structure-Activity/Structure-Property Relationship (nano-QSAR/QSPR) tools for risk assessment are analyzed, including modeling methods and validation procedures towards the potential of these computational instruments to meet the current requirements for authorization of nanoformulations. Future trends on these issues, of pressing importance within the context of the current European pesticide legislative framework, are also discussed. Standard protocols to make high-quality and well-described datasets for the series of related but differently sized nanoparticles/nanopesticides are required.
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