细胞内
效应器
细胞生物学
细胞外基质
免疫系统
细胞骨架
信号
功能(生物学)
受体
生物
细胞外
细胞
免疫学
遗传学
生物化学
出处
期刊:Nature Reviews Immunology
[Springer Nature]
日期:2017-07-31
卷期号:17 (11): 679-690
被引量:339
摘要
Leukocytes can completely reorganize their cytoskeletal architecture within minutes. This structural plasticity, which facilitates their migration and communicative function, also enables them to exert a substantial amount of mechanical force against the extracellular matrix and the surfaces of interacting cells. In recent years, it has become increasingly clear that these forces have crucial roles in immune cell activation and subsequent effector responses. Here, I review our current understanding of how mechanical force regulates cell-surface receptor activation, cell migration, intracellular signalling and intercellular communication, highlighting the biological ramifications of these effects in various immune cell types.
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