腹泻
医学
接种疫苗
产肠毒素大肠杆菌
死亡率
抗菌剂
疾病
疫苗效力
抗生素
内科学
兽医学
免疫学
微生物学
生物
大肠杆菌
基因
肠毒素
生物化学
作者
Radoslaw Romanowski,Rick Culbert,Stan Alkemade,Maira J. Medellin-Peña,Dejan Bugarski,Aleksandar Milovanović,Slađan Nešić,Aleksandar Mašić
出处
期刊:Acta Veterinaria-beograd
[De Gruyter]
日期:2017-06-01
卷期号:67 (2): 222-237
被引量:8
标识
DOI:10.1515/acve-2017-0019
摘要
Abstract Calf diarrhea is a common disease in young animals and the primary cause of productivity and economic losses to cattle producers worldwide. According to the report from the National Animal Health Monitoring System for U.S. dairy, more than fifty percent of the deaths of un-weaned calves is attributed to severe diarrhea. Enterotoxigenic Escherichia coli (ETEC) strain K99 + remains the most common pathogen isolated from calves which are younger than three days of age. Dam vaccination and the use of antimicrobials remain the most used prophylactic and treatment options for calf diarrhea. The rise in antibiotic resistance around the world has been a major concern and new alternative therapies have been explored. Mycobacterium Cell Wall Fraction (MCWF) is a biological immunomodulator that has a potential in multiple veterinary health services such as the treatment and prevention of infectious diseases and anticancer therapy in both small and large animals. The efficacy of the MCWF in reducing the severity of neonatal calf diarrhea and its associated mortality, following challenge with ETEC K99 + was evaluated. Twenty-three calves were placed into two experimental groups. Eleven calves received a single 1 mL dose of MCWF intravenously (IV) at the onset of clinical signs of disease following challenge. Twelve non-treated, challenged calves were retained as controls. The severity and duration of diarrhea was significantly reduced in the MCWF treated group compared to untreated controls. In addition, the mortality rate in the MCWF treated group was significantly reduced to 10% while the observed mortality in the control group reached 58%. Data from the current study suggest that MCWF could be used as an alternative treatment to reduce the severity, duration and mortality of ETEC induced diarrhea in neonatal calves.
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