巨噬细胞极化
血管生成
生物
巨噬细胞
表型
先天免疫系统
癌症研究
肿瘤微环境
免疫学
免疫抑制
癌细胞
细胞生物学
癌症
免疫系统
体外
基因
遗传学
作者
Antonio Sica,Paola Larghi,Alessandra Mancino,Luca Rubino,Chiara Porta,Maria Grazia Totaro,Monica Rimoldi,Subhra K. Biswas,Paola Allavena,Alberto Mantovani
标识
DOI:10.1016/j.semcancer.2008.03.004
摘要
Macrophages are a fundamental part of the innate defense mechanisms, which can promote specific immunity by inducing T cell recruitment and activation. Despite this, their presence within the tumour microenvironment has been associated with enhanced tumour progression and shown to promote cancer cell growth and spread, angiogenesis and immunosuppression. This paradoxical role of macrophages in cancer finds an explanation in their functional plasticity, that may result in the polarized expression of either pro- or anti-tumoural functions. Key players in the setting of their phenotype are the microenvironmental signals to which macrophages are exposed, which selectively tune their functions within a functional spectrum encompassing the M1 and M2 extremes. Here, we discuss recent findings suggesting that targeting tumour-associated macrophages (TAMs) polarization may represent a novel therapeutic strategy against cancer.
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