白色念珠菌
生物
免疫系统
模式识别受体
免疫
微生物学
免疫学
先天免疫系统
葡聚糖
髓系细胞
受体
葡萄聚糖
白色体
生物化学
作者
Philip R. Taylor,S. Vicky Tsoni,Janet A. Willment,Kevin M. Dennehy,Marcela Rosas,Helen Findon,Ken Haynes,Chad Steele,Marina Botto,Siamon Gordon,Gordon D. Brown
摘要
β-Glucan is one of the most abundant polysaccharides in fungal pathogens, yet its importance in antifungal immunity is unclear. Here we show that deficiency of dectin-1, the myeloid receptor for β-glucan, rendered mice susceptible to infection with Candida albicans. Dectin-1-deficient leukocytes demonstrated significantly impaired responses to fungi even in the presence of opsonins. Impaired leukocyte responses were manifested in vivo by reduced inflammatory cell recruitment after fungal infection, resulting in substantially increased fungal burdens and enhanced fungal dissemination. Our results establish a fundamental function for β-glucan recognition by dectin-1 in antifungal immunity and demonstrate a signaling non–Toll-like pattern-recognition receptor required for the induction of protective immune responses.
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