Implication of 5-HT2A subtype receptors in DOI activity in the four-plates test–retest paradigm in mice

抗焦虑药 兴奋剂 焦虑症 敌手 药理学 受体拮抗剂 对抗 受体 5-HT2C受体 5-羟色胺受体 高架加迷宫 血清素 心理学 行为绝望测验 化学 内科学 内分泌学 焦虑 医学 抗抑郁药 精神科 生物化学
作者
Nadège Ripoll,Martine Hascoët,Michel Bourin
出处
期刊:Behavioural Brain Research [Elsevier BV]
卷期号:166 (1): 131-139 被引量:35
标识
DOI:10.1016/j.bbr.2005.07.013
摘要

The four-plates test (FPT) is an animal model of anxiety which allows the detection of anxiolytic effect not only of benzodiazepines (BZDs) but also of other non-BZDs anxiolytic compounds such as antidepressants (ADs). Furthermore, DOI, a 5-HT 2A/2C agonist, has been shown to exert an anxiolytic-like effect in this model. Retesting mice in animal models of anxiety (test–retest paradigm) induces an anxiogenic-like and a loss of anxiolytic-like effects in response to BZDs and ADs. On the contrary, DOI has been reported to oppose the fear potentiation induced by trial 1 in the FPT. Despite DOI is considered as one of the most selective 5-HT 2A available, it acts as agonist at all three 5-HT 2 receptor subtypes (5-HT 2A , 5-HT 2B and 5-HT 2C ). The aim of this study was thus to investigate in the FPT test–retest paradigm, which 5-HT 2 receptor subtype(s) was involved in the DOI-induced effect in experienced mice. The effect of DOI (0.25–4 mg/kg) and the agonists, 5-HT 2B , BW 723C86 (1–16 mg/kg) and 5-HT 2C , RO 60-0175 (0.25–4 mg/kg) have also been studied. Then, antagonism studies were conducted combinating the 5-HT 2A receptor antagonist SR 46349B, the 5-HT 2B/2C receptor antagonist SB 206553 or the selective 5-HT 2C receptor antagonist RS 10-2221 (at the doses of 0.1 and 1 mg/kg) with the DOI (1 mg/kg). Our study shows that the BW 723C86 had no effect on retesting mice, whereas it exerted an anxiolytic-like effect in naive mice. By contrast to DOI, the RO 60-0175 had no effect neither in naive nor experienced mice. Furthermore, only the SR 46349B antagonized the DOI-induced anti-punishment effect. Diazepam included as a positive control also increased in each case the number of punished passages in naive mice. Our findings altogether also suggest that DOI exerts its anxiolytic-like effect in the FPT test–retest paradigm through 5-HT 2A receptors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
luxkex完成签到,获得积分10
刚刚
刚刚
奶黄包发布了新的文献求助10
刚刚
有求必_应完成签到,获得积分10
1秒前
2秒前
ShuY完成签到,获得积分10
2秒前
careyzhou发布了新的文献求助10
2秒前
Ran-HT完成签到,获得积分10
3秒前
开小森发布了新的文献求助10
4秒前
科研通AI2S应助荒野风采纳,获得10
4秒前
闫木木完成签到,获得积分10
5秒前
邪恶青年完成签到,获得积分10
5秒前
xuan完成签到,获得积分10
5秒前
yahonyoyoyo发布了新的文献求助10
6秒前
135完成签到 ,获得积分10
8秒前
sl发布了新的文献求助10
8秒前
aldehyde应助yahonyoyoyo采纳,获得10
9秒前
坚强莺完成签到,获得积分10
9秒前
9秒前
yxrose完成签到,获得积分10
9秒前
巫马逊完成签到,获得积分10
9秒前
hb完成签到,获得积分10
9秒前
10秒前
科研通AI2S应助livra1058采纳,获得10
10秒前
10秒前
松柏完成签到 ,获得积分10
11秒前
11秒前
11秒前
激昂的南烟完成签到 ,获得积分10
11秒前
科研小白完成签到,获得积分10
11秒前
早点睡吧完成签到,获得积分10
12秒前
xinxinbaby完成签到,获得积分10
13秒前
完美世界应助谨慎的擎宇采纳,获得10
13秒前
乌拉拉发布了新的文献求助10
13秒前
大个应助欣欣采纳,获得10
13秒前
斯文败类应助机灵又蓝采纳,获得30
13秒前
各个器官完成签到 ,获得积分10
14秒前
cgh发布了新的文献求助10
14秒前
14秒前
量子星尘发布了新的文献求助10
15秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029