法尼甾体X受体
胆汁酸
G蛋白偶联胆汁酸受体
核受体
胃肠道
受体
生物
炎症性肠病
信号转导
内科学
细胞生物学
医学
生物化学
疾病
转录因子
基因
作者
Lili Ding,Li Yang,Zhengtao Wang,Wendong Huang
标识
DOI:10.1016/j.apsb.2015.01.004
摘要
Bile acids (BAs) are not only digestive surfactants but also important cell signaling molecules, which stimulate several signaling pathways to regulate some important biological processes. The bile-acid-activated nuclear receptor, farnesoid X receptor (FXR), plays a pivotal role in regulating bile acid, lipid and glucose homeostasis as well as in regulating the inflammatory responses, barrier function and prevention of bacterial translocation in the intestinal tract. As expected, FXR is involved in the pathophysiology of a wide range of diseases of gastrointestinal tract, including inflammatory bowel disease, colorectal cancer and type 2 diabetes. In this review, we discuss current knowledge of the roles of FXR in physiology of the digestive system and the related diseases. Better understanding of the roles of FXR in digestive system will accelerate the development of FXR ligands/modulators for the treatment of digestive system diseases.
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