The use of dixon plots to study enzyme inhibition

1. The use of the Dixon method of plotting enzyme inhibition data is considered for case where the interaction between the inhibitor and enzyme is more complex than for classical competitive and non-competitive inhibition. It is concluded that the use of Dixon plots in conjunction with Lineweaver-Burk plots can be a valuable aid in the identification of inhibition behaviour. 2. The inhibition patterns considered include mixed, hyperbolic-competitive and two forms of uncompetitive inhibition.