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Effects of working memory training on functional connectivity and cerebral blood flow during rest

默认模式网络 静息状态功能磁共振成像 楔前 神经科学 前额叶皮质 心理学 脑血流 神经可塑性 后扣带 工作记忆 大脑活动与冥想 后顶叶皮质 皮质(解剖学) 功能连接 功能磁共振成像 认知 心脏病学 医学 脑电图
作者
Hikaru Takeuchi,Yasuyuki Taki,Rui Nouchi,Hiroshi Hashizume,Atsushi Sekiguchi,Yuka Kotozaki,Seishu Nakagawa,Calros M. Miyauchi,Yuko Sassa,Ryuta Kawashima
出处
期刊:Cortex [Elsevier BV]
卷期号:49 (8): 2106-2125 被引量:133
标识
DOI:10.1016/j.cortex.2012.09.007
摘要

Working memory (WM) training (WMT) alters the task-related brain activity and structure of the external attention system (EAS). We investigated whether WMT also alters resting-state brain mechanisms, which are assumed to reflect intrinsic brain activity and connectivity. Our study subjects were subjected to a 4-week WMT program and brain scans before and after the intervention for determining changes of functional connectivity and regional cerebral blood flow during rest (resting-FC/resting-rCBF). Compared with no-intervention, WMT (a) increased resting-FC between the medial prefrontal cortex (mPFC) and precuneus, which are key nodes of the default mode network (DMN), (b) decreased resting-FC between mPFC and the right posterior parietal cortex/right lateral prefrontal cortex (LPFC), which are key nodes of the EAS, and (c) increased resting-rCBF in the right LPFC. However, the training-related decreases in resting-FC between the key DMN node and the nodes of EAS were only observed when the whole brain signal was regressed out in individual analyses, and these changes were not observed when the whole brain signal was not regressed out in individual analyses. Further analyses indicated that these differences may be mediated by a weak but a widespread increase in resting-FC between the nodes of EAS and activity of multiple bilateral areas across the brain. These results showed that WMT induces plasticity in neural mechanisms involving DMN and the EAS during rest and indicated that intrinsic brain activity and connectivity can be affected by cognitive training.
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