转录因子
细胞生物学
生物
平衡
能量稳态
叉头转录因子
上游和下游(DNA)
基因表达调控
受体
基因
遗传学
上游(联网)
计算机网络
计算机科学
作者
Astrid Eijkelenboom,Boudewijn Burgering
摘要
Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle, apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell maintenance and lifespan as well as age-related diseases, such as cancer and diabetes. Multiple upstream pathways regulate FOXO activity through post-translational modifications and nuclear-cytoplasmic shuttling of both FOXO and its regulators. The diversity of this upstream regulation and the downstream effects of FOXOs suggest that they function as homeostasis regulators to maintain tissue homeostasis over time and coordinate a response to environmental changes, including growth factor deprivation, metabolic stress (starvation) and oxidative stress.
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