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Green tea catechin inhibits lipopolysaccharide-induced bone resorptionin vivo

骨吸收 破骨细胞 兰克尔 化学 脂多糖 吸收 内科学 内分泌学 体内 骨保护素 分子生物学 受体 医学 生物化学 生物 激活剂(遗传学) 生物技术
作者
Hirotaka Nakamura,Takashi Ukai,Atsutoshi Yoshimura,Y. Kozuka,Hidenobu Yoshioka,Yasunori Yoshinaga,Y. Abe,Yoshitaka Hara
出处
期刊:Journal of Periodontal Research [Wiley]
卷期号:45 (1): 23-30 被引量:62
标识
DOI:10.1111/j.1600-0765.2008.01198.x
摘要

Bone resorption is positively regulated by receptor activator of nuclear factor-kappaB ligand (RANKL). Pro-inflammatory cytokines, such as interleukin (IL)-1beta, promote RANKL expression by stromal cells and osteoblasts. Green tea catechin (GTC) has beneficial effects on human health and has been reported to inhibit osteoclast formation in an in vitro co-culture system. However, there has been no investigation of the effect of GTC on periodontal bone resorption in vivo. We therefore investigated whether GTC has an inhibitory effect on lipopolysaccharide (LPS)-induced bone resorption.Escherichia coli (E. coli) LPS or LPS with GTC was injected a total of 10 times, once every 48 h, into the gingivae of BALB/c mice. Another group of mice, housed with free access to water containing GTC throughout the experimental period, were also injected with LPS in a similar manner.The alveolar bone resorption and IL-1beta expression induced by LPS in gingival tissue were significantly decreased by injection or oral administration of GTC. Furthermore, when GTC was added to the medium, decreased responses to LPS were observed in CD14-expressing Chinese hamster ovary (CHO) reporter cells, which express CD25 through LPS-induced nuclear factor-kappaB (NF-kappaB) activation. These findings demonstrated that GTC inhibits nuclear translocation of NF-kappaB activated by LPS. In addition, osteoclasts were generated from mouse bone marrow macrophages cultured in a medium containing RANKL and macrophage colony-stimulating factor with or without GTC. The number of osteoclasts was decreased in dose-dependent manner when GTC was added to the culture medium.These results suggest that GTC suppresses LPS-induced bone resorption by inhibiting IL-1beta production or by directly inhibiting osteoclastogenesis.
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