上游激活序列
抄写(语言学)
发起人
转录因子
DNA结合域
DNA
细胞生物学
DNA结合蛋白
生物
结合位点
基因
分子生物学
化学
生物化学
基因表达
哲学
语言学
作者
Janice A. Fischer,Edward Giniger,Tom Maniatis,Mark Ptashne
出处
期刊:Nature
[Springer Nature]
日期:1988-04-01
卷期号:332 (6167): 853-856
被引量:465
摘要
GAL4 is a yeast regulatory protein that binds to specific sites within a DNA sequence called UASG (galactose upstream activating sequence) and activates transcription of linked genes. This activation requires two functions of the protein: a DNA binding domain located near the amino terminus, and one or more 'activating regions'. The 'activating regions' are highly acidic (see also ref. 12) and can be replaced, for example, by a short peptide designed to form a negatively charged, amphipathic alpha-helix. GAL4, as well as deletion derivatives bearing one or more 'activating regions' attached to the DNA binding domain, activates transcription in cultured mammalian cells from mammalian promoters linked to a UASG (refs 14, 15). Here we show that GAL4, when expressed in particular tissues of Drosophila larvae, stimulates tissue-specific transcription of a Drosophila promoter linked to GAL4 binding sites.
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