转移
细胞凋亡
程序性细胞死亡
干细胞
癌症研究
生物
癌症干细胞
体内
癌细胞
机制(生物学)
癌症
体外
功能(生物学)
细胞生物学
遗传学
认识论
哲学
作者
Patrick Mehlen,Alain Puisieux
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2006-05-24
卷期号:6 (6): 449-458
被引量:1776
摘要
The metastatic process is highly inefficient--very few of the many cells that migrate from the primary tumour successfully colonize distant sites. One proposed mechanism to explain this inefficiency is provided by the cancer stem cell model, which hypothesizes that micrometastases can only be established by tumour stem cells, which are few in number. However, recent in vitro and in vivo observations indicate that apoptosis is an important process regulating metastasis. Here we stress that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells.
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