四极离子阱
离子阱
存水弯(水管)
质谱法
自上而下的蛋白质组学
翻译后修饰
三级四极质谱仪
离子
化学
四极
表征(材料科学)
混合质谱仪
蛋白质组学
分析化学(期刊)
选择性反应监测
串联质谱法
色谱法
材料科学
物理
纳米技术
原子物理学
生物化学
有机化学
气象学
基因
酶
出处
期刊:Drug Discovery Today: Targets
[Elsevier]
日期:2004-04-01
卷期号:3 (2): 31-36
被引量:3
标识
DOI:10.1016/s1741-8372(04)02421-1
摘要
Mass spectrometry (MS) can play an important part in the characterization of protein posttranslational modifications. The specificity of triple-quadrupole scan modes combined with the sensitivity of the linear ion-trap operational modes in Q TRAP™ MS instruments presents new opportunities for automated investigation of posttranslational modifications in biological samples. The triple-quadrupole precursor ion and constant neutral loss scans are very powerful for identifying peptides that have been posttranslationally modified. In addition, the ion-trap product ion scans can provide valuable information for amino acid sequence determination and sites of modification.
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