亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Kidney Transplant Recipients with Post-transplant Diabetes Mellitus (PTDM)- a Systematic Review and Meta-Analysis

医学 磷酸西他列汀 内科学 糖尿病 2型糖尿病 他克莫司 血糖性 荟萃分析 临床终点 安慰剂 二肽基肽酶-4 移植 胃肠病学 随机对照试验 胰岛素 2型糖尿病 内分泌学 替代医学 病理
作者
Tarek Abdelaziz,Ahmed Yamany Ali,Moataz Fatthy
出处
期刊:Current Diabetes Reviews [Bentham Science]
卷期号:16 (6): 580-585 被引量:12
标识
DOI:10.2174/1573399815666190321144310
摘要

Background: Kidney transplant recipients may develop post-transplant diabetes mellitus (PTDM). Dipeptidyl peptidase 4(DPP-4) inhibitors are evolving agents in the management of patients with diabetes mellitus. Aims: To evaluate the efficacy and safety of DPP-4 inhibitors in the management of post-transplant diabetes mellitus (PTDM) in renal transplant recipients. Methods: We performed a systematic search of the electronic databases using keys words and Mesh terms. Data were extracted and reviewed using structured proforma. A comprehensive review of the eligible studies was performed independently by each of two reviewers; conflicts were resolved by the third reviewer. The primary efficacy endpoint was the difference in glycosylated hemoglobin (HbA1c) comparing any of the DPP-4 inhibitors to either placebo or other hypoglycaemic agent. The primary safety endpoints were the worsening of graft functions and change in Tacrolimus trough level. We performed the Random effect model using standardised mean difference. Results: We identified seven studies that were eligible for the systematic review; only one study compared Sitagliptin to insulin Glargine. One study involved head to head comparison of three DPP-4 inhibitors. The other five studies were pooled in the meta-analysis. DPP-4 inhibitors had a favourable glycemic effect as measured by HbA1c when compared to either placebo or oral anti-hyperglycemic medications (standardised mean difference in HbA1c = -0.993, 95% CI= -1.303 to -0.683, P=0.001). DPP-4 inhibitors use did not result in significant change in eGFR ((standardised mean difference = 0.147, 95% CI= -0.139 - 0.433, p=0.312).) nor Tacrolimus level (standardised Mean Difference= 0.152, 95% CI= -0.172 to 0.477, P=0.354). Conclusion: Current evidence supports the short term efficacy and safety of DDP-4 inhibitor agents in the management of post transplantation diabetes mellitus (PTDM) in kidney transplant recipients. However, more RCTs are required to investigate the long-term safety and efficacy of these agents in kidney transplant recipients.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2分钟前
3分钟前
Ann完成签到,获得积分10
4分钟前
桃汁荔枝完成签到 ,获得积分10
4分钟前
连安阳完成签到,获得积分10
4分钟前
zsmj23完成签到 ,获得积分0
4分钟前
丘比特应助科研通管家采纳,获得30
4分钟前
田様应助科研通管家采纳,获得80
4分钟前
Hello应助科研通管家采纳,获得10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
4分钟前
顾矜应助方方采纳,获得10
6分钟前
桃汁荔枝关注了科研通微信公众号
6分钟前
6分钟前
方方发布了新的文献求助10
6分钟前
sharronjxx应助方方采纳,获得10
6分钟前
方方完成签到,获得积分10
6分钟前
慕青应助科研通管家采纳,获得10
6分钟前
稻子完成签到 ,获得积分10
7分钟前
空曲完成签到 ,获得积分10
7分钟前
11分钟前
11分钟前
吕懿发布了新的文献求助10
11分钟前
标致诗双发布了新的文献求助10
11分钟前
大个应助吕懿采纳,获得10
12分钟前
12分钟前
标致诗双完成签到,获得积分10
13分钟前
14分钟前
大模型应助摇摇猪采纳,获得10
17分钟前
17分钟前
新奇完成签到 ,获得积分10
17分钟前
小蘑菇应助oleskarabach采纳,获得10
18分钟前
通科研完成签到 ,获得积分10
19分钟前
19分钟前
科研通AI2S应助谢小卷采纳,获得20
19分钟前
20分钟前
摇摇猪发布了新的文献求助10
20分钟前
luckbee完成签到,获得积分10
20分钟前
张小咩咩完成签到 ,获得积分10
20分钟前
摇摇猪完成签到,获得积分10
20分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052540
求助须知:如何正确求助?哪些是违规求助? 2709817
关于积分的说明 7418203
捐赠科研通 2354370
什么是DOI,文献DOI怎么找? 1245934
科研通“疑难数据库(出版商)”最低求助积分说明 605934
版权声明 595921