机械敏感通道
生物
细胞生物学
干细胞
机械生物学
机械反应
细胞外基质
机械转化
细胞
细胞分化
离子通道
遗传学
基因
受体
作者
Li He,Muhammad Ahmad,Norbert Perrimon
标识
DOI:10.1016/j.yexcr.2018.11.016
摘要
Stem cells continuously perceive and respond to various environmental signals during development, tissue homeostasis, and pathological conditions. Mechanical force, one of the fundamental signals in the physical world, plays a vital role in the regulation of multiple functions of stem cells. The importance of cell adhesion to the extracellular matrix (ECM), cell-cell junctions, and a mechanoresponsive cell cytoskeleton has been under intensive study in the fields of stem cell biology and mechanobiology. However, the involvement of mechanosensitive (MS) ion channels in the mechanical regulation of stem cell activity has just begun to be realized. Here, we review the diversity and importance of mechanosensitive channels (MSCs), and discuss recently discovered functions of MSCs in stem cell regulation, especially in the determination of cell fate.
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