染色质
重编程
全能的
生物
诱导多能干细胞
细胞命运测定
细胞生物学
组蛋白
异染色质
转录因子
神经科学
细胞分化
遗传学
基因
细胞
胚胎干细胞
DNA
作者
Tejas Yadav,Jean‐Pierre Quivy,Geneviève Almouzni
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-09-28
卷期号:361 (6409): 1332-1336
被引量:154
标识
DOI:10.1126/science.aat8950
摘要
During development and throughout life, a variety of specialized cells must be generated to ensure the proper function of each tissue and organ. Chromatin plays a key role in determining cellular state, whether totipotent, pluripotent, multipotent, or differentiated. We highlight chromatin dynamics involved in the generation of pluripotent stem cells as well as their influence on cell fate decision and reprogramming. We focus on the capacity of histone variants, chaperones, modifications, and heterochromatin factors to influence cell identity and its plasticity. Recent technological advances have provided tools to elucidate the underlying chromatin dynamics for a better understanding of normal development and pathological conditions, with avenues for potential therapeutic application.
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