壳聚糖
止血剂
化学
止血
生物材料
生物相容性材料
抗菌活性
生物医学工程
生物化学
有机化学
细菌
外科
医学
遗传学
生物
作者
Julia Radwan-Pragłowska,Marek Piątkowski,Volodymyr Deineka,Łukasz Janus,Viktoriia Korniienko,Yevheniia Husak,Viktoriia Mykolaivna Holubnycha,Iryna Liubchak,В. О. Журба,Aleksandra Sierakowska,Maksym Pogorielov,Dariusz Bogdał
出处
期刊:Molecules
[MDPI AG]
日期:2019-07-19
卷期号:24 (14): 2629-2629
被引量:73
标识
DOI:10.3390/molecules24142629
摘要
Massive blood loss is responsible for numerous causes of death. Hemorrhage may occur on the battlefield, at home or during surgery. Commercially available biomaterials may be insufficient to deal with excessive bleeding. Therefore novel, highly efficient hemostatic agents must be developed. The aim of the following research was to obtain a new type of biocompatible chitosan-based hemostatic agents with increased hemostatic properties. The biomaterials were obtained in a quick and efficient manner under microwave radiation using l-aspartic and l-glutamic acid as crosslinking agents with no use of acetic acid. Ready products were investigated over their chemical structure by FT-IR method which confirmed a crosslinking process through the formation of amide bonds. Their high porosity above 90% and low density (below 0.08 g/cm3) were confirmed. The aerogels were also studied over their water vapor permeability and antioxidant activity. Prepared biomaterials were biodegradable in the presence of human lysozyme. All of the samples had excellent hemostatic properties in contact with human blood due to the platelet activation confirmed by blood clotting tests. The SEM microphotographs showed the adherence of blood cells to the biomaterials’ surface. Moreover, they were biocompatible with human dermal fibroblasts (HDFs). The biomaterials also had superior antibacterial properties against both Staphylococcus aureus and Escherichia coli. The obtained results showed that proposed chitosan-based hemostatic agents have great potential as a hemostatic product and may be applied under sterile, as well as contaminated conditions, by both medicals and individuals.
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