环肽
药物发现
药物开发
计算生物学
药品
杠杆(统计)
肽
药理学
生物
计算机科学
生物信息学
生物化学
人工智能
作者
Jingjing Zhang,Jimin Yuan,Zhijie Li,Chunjin Fu,Menglong Xu,Jing Yang,Xin Jiang,Boping Zhou,Xiufeng Ye,Chengchao Xu
摘要
Abstract Ever since the discovery of insulin, natural peptides have become an important resource for therapeutic development. Decades of research has led to the discovery of a long list of peptide drugs with broad applications in clinics, from antibiotics to hypertension treatment to pain management. Many of these US FDA‐approved peptide drugs are derived from microorganisms and animals. By contrast, the great potential of plant cyclic peptides as therapeutics remains largely unexplored. These macrocyclic peptides typically have rigid structures, good bioavailability and membrane permeability, making them appealing candidates for drug development and engineering. In this review, we introduce the three major classes of plant cyclic peptides and summarize their potential medical applications. We discuss how we can leverage the genome information of many different plants to quickly search for new cyclic peptides and how we can take advantage of the insights gained from their biosynthetic pathways to transform the process of production and drug development. These recent developments have provided a new angle for exploring and exploiting plant cyclic peptides, and we believe that many more peptide drugs derived from plants are about to come.
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