医学
铁蛋白
造血干细胞移植
回顾性队列研究
内科学
移植
急性白血病
胃肠病学
骨髓增生异常综合症
血液病
疾病
外科
白血病
骨髓
作者
Funda Tayfun Küpesiz,Volkan Hazar,Nurşah Eker,Elif Güler,M. Akif Yeşilipek,Gülen Tüysüz,Alphan Küpesiz
出处
期刊:Journal of Pediatric Hematology Oncology
[Ovid Technologies (Wolters Kluwer)]
日期:2020-05-15
卷期号:42 (5): e315-e320
被引量:2
标识
DOI:10.1097/mph.0000000000001829
摘要
Background: Hematopoietic stem cell transplantation (HSCT) is a curative therapy option for hematologic malignancies. Iron overload is common in this patient group and can impact short-term and long-term nonrelapse mortality. Study Design: Retrospective observational cohort study. Aims: To evaluate the effect of iron load on early and late HSCT outcomes in patients with acute leukemia and myelodysplasia to assess the necessity of reducing iron load. Patients and Methods: Sixty patients who underwent HSCT in pediatric stem cell transplantation unit between 2000 and 2012 were evaluated retrospectively. The patients were divided into those with pretransplantation serum ferritin levels above and below the median value of 1299 ng/mL. Results: Forty-two (70%) of the patients were male, mean ages of the low and high ferritin groups were 85.43±9.42 and 118.56±10.04 months, respectively. Acute graft-versus-host disease (GVHD) within the first 100 days and acute liver GVHD were significantly more common in the high ferritin group ( P <0.011 for both). Ferritin level was not associated with rates of engraftment syndrome, veno-occlusive disease, early/late infection, relapse, or overall and disease-free survival. Conclusions: In our study, significant result especially in terms of acute liver GVHD, was important to emphasize the need to be more careful in terms of acute liver GVHD risk in early liver pathologies in patients with high levels of ferritin after transplantation. In future large studies may be helpful to explain the relationship between acute liver GVHD and high ferritin levels.
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