Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals

全基因组关联研究 双相情感障碍 汉族 单核苷酸多态性 精神分裂症(面向对象编程) 基因型 医学 遗传学 人口 精神科 生物 心情 基因 环境卫生
作者
Huijuan Li,Chen Zhang,Hui Li,Dongsheng Zhou,Yi Li,Chuyi Zhang,Chuang Wang,Lu Wang,Wenqiang Li,Yongfeng Yang,Na Qu,Jinsong Tang,Ying Hé,Jun Zhou,Zihao Yang,Xingxing Li,Jun Cai,Lu Yang,Jun Chen,Weixing Fan,Wei Tang,Wenxin Tang,Qi Jia,Weiqing Liu,Chuanjun Zhuo,Xueqin Song,Fang Liu,Yan Bai,Bao‐Liang Zhong,Shufang Zhang,Jing Chen,Bin Xia,Luxian Lv,Zhongchun Liu,Shaohua Hu,Xiaoyan Li,Jie-wei Liu,Xin Cai,Yong-Gang Yao,Yuyanan Zhang,Hao Yan,Suhua Chang,Jingping Zhao,Weihua Yue,Xiong-Jian Luo,Xiaogang Chen,Xiao Xiao,Yiru Fang,Ming Li
出处
期刊:JAMA Psychiatry [American Medical Association]
卷期号:78 (3): 320-320 被引量:35
标识
DOI:10.1001/jamapsychiatry.2020.3738
摘要

The genetic basis of bipolar disorder (BD) in Han Chinese individuals is not fully understood.To explore the genetic basis of BD in the Han Chinese population.A genome-wide association study (GWAS), followed by independent replication, was conducted to identify BD risk loci in Han Chinese individuals. Individuals with BD were diagnosed based on DSM-IV criteria and had no history of schizophrenia, mental retardation, or substance dependence; individuals without any personal or family history of mental illnesses, including BD, were included as control participants. In total, discovery samples from 1822 patients and 4650 control participants passed quality control for the GWAS analysis. Replication analyses of samples from 958 patients and 2050 control participants were conducted. Summary statistics from the European Psychiatric Genomics Consortium 2 (PGC2) BD GWAS (20 352 cases and 31 358 controls) were used for the trans-ancestry genetic correlation analysis, polygenetic risk score analysis, and meta-analysis to compare BD genetic risk between Han Chinese and European individuals. The study was performed in February 2020.Single-nucleotide variations with P < 5.00 × 10-8 were considered to show genome-wide significance of statistical association.The Han Chinese discovery GWAS sample included 1822 cases (mean [SD] age, 35.43 [14.12] years; 838 [46%] male) and 4650 controls (mean [SD] age, 27.48 [5.97] years; 2465 [53%] male), and the replication sample included 958 cases (mean [SD] age, 37.82 [15.54] years; 412 [43%] male) and 2050 controls (mean [SD] age, 27.50 [6.00] years; 1189 [58%] male). A novel BD risk locus in Han Chinese individuals was found near the gene encoding transmembrane protein 108 (TMEM108, rs9863544; P = 2.49 × 10-8; odds ratio [OR], 0.650; 95% CI, 0.559-0.756), which is required for dendritic spine development and glutamatergic transmission in the dentate gyrus. Trans-ancestry genetic correlation estimation (ρge = 0.652, SE = 0.106; P = 7.30 × 10-10) and polygenetic risk score analyses (maximum liability-scaled Nagelkerke pseudo R2 = 1.27%; P = 1.30 × 10-19) showed evidence of shared BD genetic risk between Han Chinese and European populations, and meta-analysis identified 2 new GWAS risk loci near VRK2 (rs41335055; P = 4.98 × 10-9; OR, 0.849; 95% CI, 0.804-0.897) and RHEBL1 (rs7969091; P = 3.12 × 10-8; OR, 0.932; 95% CI, 0.909-0.956).This GWAS study identified several loci and genes involved in the heritable risk of BD, providing insights into its genetic architecture and biological basis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
秋天完成签到,获得积分10
2秒前
淡定的惜关注了科研通微信公众号
5秒前
Zhy发布了新的文献求助10
5秒前
6秒前
蛋挞完成签到,获得积分10
8秒前
李健应助Junning采纳,获得10
10秒前
10秒前
tingting9发布了新的文献求助10
11秒前
12秒前
爆米花应助mark采纳,获得10
13秒前
13秒前
爱看文献的小恐龙完成签到,获得积分10
14秒前
小饼干完成签到 ,获得积分10
16秒前
萧瑟处完成签到 ,获得积分10
17秒前
17秒前
18秒前
孙燕应助鹤鸣采纳,获得30
19秒前
20秒前
loski发布了新的文献求助10
22秒前
随便不放假完成签到 ,获得积分10
23秒前
淡定的惜发布了新的文献求助10
25秒前
威武的亦绿完成签到,获得积分10
25秒前
木丁完成签到,获得积分10
26秒前
26秒前
29秒前
量子星尘发布了新的文献求助30
31秒前
孙燕应助成就山河采纳,获得10
32秒前
33秒前
领导范儿应助幸福大白采纳,获得30
34秒前
谓风发布了新的文献求助10
34秒前
35秒前
q1356478314应助天白采纳,获得10
35秒前
Hanni完成签到 ,获得积分10
35秒前
36秒前
yixiaolou发布了新的文献求助10
36秒前
Junning发布了新的文献求助10
37秒前
38秒前
38秒前
认真的傲柏完成签到,获得积分10
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174