Effect of amisulpride combined with low-frequency repetitive transcranial electrical stimulation on serum leptin level and extrapyramidal symptoms in patients with first-episode schizophrenia

Objective To study the effect of amisulpride combined with low-frequency repetitive transcranial electrical stimulation on the serum leptin level and extrapyramidal symptoms in patients with first-episode schizophrenia. Methods 82 patients with first-episode schizophrenics treated at our hospital from October, 2015 to January, 2017 were divided into a control group and an observation according to different treatment protocols, 41 cases for each group. The control group were treated with amisulpride and the observation group amisulpride and low-frequency repetitive transcranial electrical stimulation. The positive and negative symptom scale (PANSS) score, negative symptom scale (SANS) score, serum leptin change, and extrapyramidal adverse reactions were compared between the two groups before and after the treatment. Results After the treatment, the PANSS score, SANS score, and serum leptin level were lower in the observation group than in the control group (all P<0.05) . There was no statistical difference in the incidence of adverse reactions of extrapyramidal symptoms between the observation group and the control group [41.46% (17/41) vs. 51.22% (21/41),χ2=0.785, P=0.376]. Conclusion Amisulpride combined with low-frequency repetitive transcranial electrical stimulation in the treatment of first-episode schizophrenia can effectively alleviate the symptoms, and reduce the serum level of leptin without increasing the extrapyramidal adverse reactions. Key words: Amisulpride; Low-frequency repetitive transcranial electrical stimulation; First-episode schizophrenia