Ocular Adverse Effects of Infigratinib, a New Fibroblast Growth Factor Receptor Tyrosine Kinase Inhibitor

Fibroblast growth factor receptors (FGFRs) are expressed in all major organs, including the eye (Fig S1, available at www.aaojournal.org). 1 Chae Y.K. Ranganath K. Hammerman P.S. et al. Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application. Oncotarget. 2017; 8: 16052-16074 Crossref PubMed Scopus (183) Google Scholar Fibroblast growth factor receptor tyrosine kinase inhibitors (TKIs) are under investigation, targeting various cancer types. 1 Chae Y.K. Ranganath K. Hammerman P.S. et al. Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application. Oncotarget. 2017; 8: 16052-16074 Crossref PubMed Scopus (183) Google Scholar Furthermore, 2 FGFR-TKIs have recently been Food and Drug Administration-approved for treating advanced urothelial carcinoma and cholangiocarcinoma. Fibroblast growth factor receptor inhibition commonly leads to hyperphosphatemia, fatigue, stomatitis, alopecia, nail changes, dry eye, and blurred vision. 2 Javle M. Lowery M. Shroff R.T. et al. Phase II study of BGJ398 in patients with FGFR-altered advanced cholangiocarcinoma. J Clin Oncol. 2018; 36: 276-282 Crossref PubMed Scopus (300) Google Scholar Re: Magone et al.: Ocular adverse effects of infigratinib, a new fibroblast growth factor receptor tyrosine kinase inhibitor (Ophthalmology. 2021;128:624–626)OphthalmologyVol. 128Issue 9PreviewWe read the article by Magone et al.1 The authors provide a useful description of the anterior segment findings in a small cohort of patients. However, we suspect there may be a discrepancy in their description of the posterior segment findings of one patient. They state that “None of the patients developed retinal pathology, including patient number 5, who had a history of reversible ingrafitinib-related bilateral retinal pigment epithelium detachments.” Although no longer present, we feel it important to comprehend this fundus abnormality fully. Full-Text PDF