生物
长非编码RNA
癌变
串扰
小RNA
增强子
基因
原癌基因蛋白质c-myc
效应器
遗传学
癌症研究
计算生物学
基因表达调控
核糖核酸
细胞生物学
基因表达
物理
光学
作者
Rongfu Tu,Zhi Chen,Qing Bao,Hudan Liu,Guoliang Qing
标识
DOI:10.1016/j.semcancer.2020.10.014
摘要
The MYC family oncoproteins are deregulated in more than 50 % of human cancers through a variety of mechanisms, such as gene amplification or translocation, super-enhancer activation, aberrant upstream signaling, and altered protein stability. As one of the major drivers in tumorigenesis, MYC regulates the expression of a large number of noncoding genes involved in multiple oncogenic processes. Noncoding RNAs, including miRNA, lncRNA, circRNA, rRNA and tRNA, are also deeply involved in the oncogenic MYC network by functioning as MYC regulators/effectors. In this review, we summarize representative studies depicting the crosstalk between oncogenic MYC and noncoding RNAs in carcinogenesis with the aim of providing potential implications for both basic science and clinical applications.
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