衰老
生物
表型
细胞周期检查点
癌症研究
细胞生物学
癌症
细胞衰老
免疫学
细胞周期
遗传学
基因
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory Press]
日期:2020-12-01
卷期号:34 (23-24): 1565-1576
被引量:811
标识
DOI:10.1101/gad.343129.120
摘要
Cellular senescence is a stress response that elicits a permanent cell cycle arrest and triggers profound phenotypic changes such as the production of a bioactive secretome, referred to as the senescence-associated secretory phenotype (SASP). Acute senescence induction protects against cancer and limits fibrosis, but lingering senescent cells drive age-related disorders. Thus, targeting senescent cells to delay aging and limit dysfunction, known as “senotherapy,” is gaining momentum. While drugs that selectively kill senescent cells, termed “senolytics” are a major focus, SASP-centered approaches are emerging as alternatives to target senescence-associated diseases. Here, we summarize the regulation and functions of the SASP and highlight the therapeutic potential of SASP modulation as complimentary or an alternative to current senolytic approaches.
科研通智能强力驱动
Strongly Powered by AbleSci AI