生物
蛋白质亚单位
抄写(语言学)
NF-κB
细胞生物学
转录因子
纤维连接蛋白
遗传学
信号转导
基因
语言学
哲学
细胞外基质
作者
Jelena Stanisavljević,Montserrat Porta-de-la-Riva,Raquel Batlle,Antonio Garcı́a de Herreros,Josep Baulida
摘要
Snail1 is a transcriptional repressor of E-cadherin that triggers epithelial–mesenchymal transition (EMT). Here, we report assisted Snail1 interaction with the promoter of a typical mesenchymal gene, fibronectin (FN1), both in epithelial cells undergoing EMT and in fibroblasts. Together with Snail1, the p65 subunit of NF-κB and PARP1 bound to the FN1 promoter. We detected nuclear interaction of these proteins and demonstrated the requirement of all three for FN1 transcription. Moreover, other genes involved in cell movement mimic FN1 expression induced by Snail1 or TGF-β1 treatment and recruit p65NF-κB and Snail1 to their promoters. The molecular cooperation between Snail1 and NF-κB in transcription activation provides a new insight into how Snail1 can modulate a variety of cell programs.
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