Carcinoembryonic Antigen as a Marker for Colorectal Cancer: Is It Clinically Useful?

癌胚抗原 医学 结直肠癌 恶性肿瘤 肿瘤科 内科学 无症状的 转移 癌症 胃肠病学
作者
Michael J. Duffy
出处
期刊:Clinical Chemistry [Oxford University Press]
卷期号:47 (4): 624-630 被引量:733
标识
DOI:10.1093/clinchem/47.4.624
摘要

Abstract Background: Carcinoembryonic antigen (CEA) is one of the most widely used tumor markers worldwide. Its main application is mostly in gastrointestinal cancers, especially in colorectal malignancy. Although in use for almost 30 years, the clinical value of CEA in colorectal cancer is still not clear. Methods: The literature relevant to the clinical value of CEA in colorectal cancer was reviewed. Particular attention was paid to studies involving metaanalyses and guidelines issued by Expert Panels. Results: Although of little use in detecting early colorectal cancer, high preoperative concentrations of CEA correlate with adverse prognosis. Serial CEA measurements can detect recurrent colorectal cancer with a sensitivity of ∼80%, a specificity of ∼70%, and can provide a lead time of ∼5 months. CEA is the most frequent indicator of recurrence in asymptomatic patients and currently is the most cost-effective test for the preclinical detection of resectable disease. CEA is most useful for the early detection of liver metastasis in patients with diagnosed colorectal cancer. Overall, however, little evidence is available that monitoring of all patients with diagnosed colorectal cancer leads to enhanced patient outcome or quality of life. Conclusions: Currently, the most useful application of CEA is in the detection of liver metastasis from colorectal cancers. Because of the relative success of surgery in resecting hepatic metastases, serial determinations of the marker are recommended for detecting cancer spread to the liver. In the future, preoperative concentrations of CEA may be included with the standard staging procedures for assessing prognosis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
今后应助19558991211采纳,获得10
刚刚
echo发布了新的文献求助10
1秒前
单纯的小松鼠完成签到,获得积分10
2秒前
CSUST科研一哥应助zjh采纳,获得20
2秒前
2秒前
3秒前
3秒前
zzt完成签到,获得积分20
3秒前
yu发布了新的文献求助10
4秒前
晓晓完成签到,获得积分20
5秒前
田様应助喽噜嘟咦呀采纳,获得10
6秒前
echo完成签到,获得积分10
6秒前
JamesPei应助back采纳,获得30
6秒前
打打应助十一采纳,获得10
6秒前
7秒前
7秒前
JamesPei应助闪亮的西瓜采纳,获得30
7秒前
晓晓发布了新的文献求助10
7秒前
可乐完成签到 ,获得积分10
8秒前
Jole完成签到,获得积分10
9秒前
9秒前
在水一方应助小吴采纳,获得10
10秒前
WXH完成签到,获得积分10
11秒前
zjq完成签到 ,获得积分10
11秒前
12秒前
丘比特应助跳跃保温杯采纳,获得10
13秒前
友好含雁发布了新的文献求助10
14秒前
14秒前
天真吴邪发布了新的文献求助10
14秒前
15秒前
再生极强的-涡虫完成签到,获得积分10
15秒前
16秒前
16秒前
17秒前
十一完成签到,获得积分20
17秒前
晚心发布了新的文献求助10
17秒前
我我我完成签到,获得积分10
20秒前
ff发布了新的文献求助10
21秒前
十一发布了新的文献求助10
21秒前
21秒前
高分求助中
The late Devonian Standard Conodont Zonation 2000
Nickel superalloy market size, share, growth, trends, and forecast 2023-2030 2000
The Lali Section: An Excellent Reference Section for Upper - Devonian in South China 1500
Very-high-order BVD Schemes Using β-variable THINC Method 870
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 800
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 800
Fundamentals of Dispersed Multiphase Flows 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3254507
求助须知:如何正确求助?哪些是违规求助? 2896674
关于积分的说明 8293818
捐赠科研通 2565675
什么是DOI,文献DOI怎么找? 1393195
科研通“疑难数据库(出版商)”最低求助积分说明 652443
邀请新用户注册赠送积分活动 630000