Study on the Efficacy of Selected Antitrematodal Drugs in Naturally Infected Sheep with Fasciolosis

An experimental type of study was designed to evaluate the efficacy of antitrematodals used in Korem and Hashenge areas of Ethiopia in naturally infected sheep with fasciolosis. 28 sheep naturally infected with fasciolosis were purchased and divided randomly into four treatment groups. Those groups were treated with triclabendazole, albendazole, oxyclozanide and a combination of albendazole and oxyclozanide. Pre-treatment Facsiola hepatica faecal egg counts per gram of faeces (EPG) were 475, 400, 533 and 317 for triclabendazole, albendazole, oxyclozanide and albendazole-oxyclozanide combination, respectively. After a week post treatment, mean egg per gram of faeces (EPG) egg count reduction test (FECRT) was (0, 100%), (100, 75%), (383, 28.14%) and (117, 63.08%) for triclabendazole, albendazole, oxyclozanide and albendazole- oxyclozanide combination, respectively. Statistical significant difference was recorded for faecal egg count reduction test percent for all the treatment groups for four weeks, but group 1 (triclabendazole) showed 100% efficacy in a single dose after seven days of treatment. However, development of drug resistance has been suspected against albendazole, oxyclozanide and albendazole-oxyclozanide combination.