Interleukin-10 promoter polymorphism in multiple sclerosis: association with disease progression.

多发性硬化 基因型 等位基因 基因分型 实验性自身免疫性脑脊髓炎 微卫星 免疫学 疾病 生物 多态性(计算机科学) 医学 基因 遗传学 内科学
作者
Lionel Almeras,Bertrand Meresse,Jérôme De Seze,de Lafuente D,Sylvain Dubucquoi,I. Fajardy,Patrick Vermersch,Lionel Prin
出处
期刊:European Cytokine Network [John Libbey Eurotext]
卷期号:13 (2): 200-6 被引量:6
标识
摘要

Interleukin-10 (IL-10) is a potent anti-inflammatory and immunosuppressive cytokine that modulates disease expression in multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). In previous studies, two dinucleotide repeat elements (microsatellites G and R) were identified, respectively located about 1.1 and 4.0 kb upstream of the IL-10 gene transcription initiation site. Several of their alleles were found to be associated with the level of IL-10 production. The aim of our study was to determine whether sequence variations in the IL-10 gene were associated with MS susceptibility and progression. To do so, we analyzed the distribution of IL-10.R and IL-10.G alleles and genotype polymorphisms in MS patients and healthy controls. We then correlated our findings with disease severity in MS patients using the progression index (PI). Patients were classified as experiencing mild (PI < 0.5) or severe (PI > 0.5) disease progression. Our results show no association between the IL-10.R microsatellite and MS, regardless of disease severity. However, IL-10.G microsatellite genotyping showed that IL-10.G9/9, G10/13, G11/13 and G13/14 were more frequently found in patients with mild disease progression (p = 0.005). We also found that in patients with severe disease progression, IL-10.G9/10, G9/11, G9/13 and G12/13 were over-represented (p = 0.002). Our study indicates that neither the IL-10.R or the IL-10.G alleles are associated with predisposition to MS. However, several IL-10.G genotypes might emerge as markers of disease progression.

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
神勇的冰姬完成签到,获得积分10
刚刚
1秒前
1秒前
1秒前
1秒前
2秒前
tony完成签到,获得积分10
2秒前
Uynaux发布了新的文献求助30
2秒前
SONG完成签到,获得积分10
2秒前
SYLH应助干秋白采纳,获得10
3秒前
3秒前
风雨1210发布了新的文献求助10
4秒前
文艺书雪完成签到 ,获得积分10
4秒前
独行侠完成签到,获得积分10
4秒前
5秒前
我测你码发布了新的文献求助10
5秒前
又要起名字完成签到,获得积分10
5秒前
5秒前
5秒前
damian完成签到,获得积分10
6秒前
LiShin发布了新的文献求助10
6秒前
渝州人应助凤凰山采纳,获得10
7秒前
sweetbearm应助凤凰山采纳,获得10
7秒前
我是老大应助科研通管家采纳,获得10
7秒前
大个应助科研通管家采纳,获得10
7秒前
yizhiGao应助科研通管家采纳,获得10
7秒前
华仔应助科研通管家采纳,获得10
7秒前
科研通AI5应助科研通管家采纳,获得30
7秒前
顾矜应助随机起的名采纳,获得10
7秒前
NN应助科研通管家采纳,获得10
7秒前
pinging应助科研通管家采纳,获得10
8秒前
星辰大海应助科研通管家采纳,获得10
8秒前
yizhiGao应助科研通管家采纳,获得10
8秒前
小蘑菇应助科研通管家采纳,获得20
8秒前
小小旋风应助科研通管家采纳,获得10
8秒前
传奇3应助科研通管家采纳,获得10
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
敬老院N号应助科研通管家采纳,获得30
8秒前
科研通AI5应助科研通管家采纳,获得10
8秒前
彭于晏应助科研通管家采纳,获得10
9秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Social media impact on athlete mental health: #RealityCheck 1020
Ensartinib (Ensacove) for Non-Small Cell Lung Cancer 1000
Unseen Mendieta: The Unpublished Works of Ana Mendieta 1000
Bacterial collagenases and their clinical applications 800
El viaje de una vida: Memorias de María Lecea 800
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3527884
求助须知:如何正确求助?哪些是违规求助? 3108006
关于积分的说明 9287444
捐赠科研通 2805757
什么是DOI,文献DOI怎么找? 1540033
邀请新用户注册赠送积分活动 716904
科研通“疑难数据库(出版商)”最低求助积分说明 709794