免疫疗法
癌症
医学
癌症免疫疗法
接种疫苗
个性化医疗
基因组学
突变
基因组
精密医学
临床试验
计算生物学
癌症研究
生物
免疫学
生物信息学
基因
遗传学
作者
Uğur Şahin,Özlem Türeci
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2018-03-22
卷期号:359 (6382): 1355-1360
被引量:843
标识
DOI:10.1126/science.aar7112
摘要
Cancer is characterized by an accumulation of genetic alterations. Somatic mutations can generate cancer-specific neoepitopes that are recognized by autologous T cells as foreign and constitute ideal cancer vaccine targets. Every tumor has its own unique composition of mutations, with only a small fraction shared between patients. Technological advances in genomics, data science, and cancer immunotherapy now enable the rapid mapping of the mutations within a genome, rational selection of vaccine targets, and on-demand production of a therapy customized to a patient’s individual tumor. First-in-human clinical trials of personalized cancer vaccines have shown the feasibility, safety, and immunotherapeutic activity of targeting individual tumor mutation signatures. With vaccination development being promoted by emerging innovations of the digital age, vaccinating a patient with individual tumor mutations may become the first truly personalized treatment for cancer.
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