声动力疗法
材料科学
纳米结构
卟啉
纳米颗粒
活性氧
轨道能级差
金属有机骨架
纳米技术
无定形碳
无定形固体
化学工程
光化学
分子
有机化学
化学
工程类
吸附
生物化学
作者
Xueting Pan,Lixin Bai,Hui Wang,Qingyuan Wu,Hongyu Wang,Shuang Liu,Bolong Xu,Xinghua Shi,Huiyu Liu
标识
DOI:10.1002/adma.201800180
摘要
Sonodynamic therapy (SDT) can overcome the critical issue of depth-penetration barrier of photo-triggered therapeutic modalities. However, the discovery of sonosensitizers with high sonosensitization efficacy and good stability is still a significant challenge. In this study, the great potential of a metal-organic-framework (MOF)-derived carbon nanostructure that contains porphyrin-like metal centers (PMCS) to act as an excellent sonosensitizer is identified. Excitingly, the superior sonosensitization effect of PMCS is believed to be closely linked to the porphyrin-like macrocycle in MOF-derived nanostructure in comparison to amorphous carbon nanospheres, due to their large highest occupied molecular orbital (HOMO)-lowest unoccupied molecular orbital (LUMO) gap for high reactive oxygen species (ROS) production. The nanoparticle-assisted cavitation process, including the visualized formation of the cavitation bubbles and microjets, is also first captured by high-speed camera. High ROS production in PMCS under ultrasound is validated by electron spin resonance and dye measurement, followed by cellular destruction and high tumor inhibition efficiency (85%). This knowledge is important from the perspective of understanding the structure-dependent SDT enhancement of a MOF-derived carbon nanostructure.
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