级联
生化工程
生物催化
催化作用
化学
组合化学
级联反应
纳米技术
有机化学
材料科学
反应机理
工程类
色谱法
作者
Josef Sperl,Volker Sieber
出处
期刊:ACS Catalysis
[American Chemical Society]
日期:2018-01-25
卷期号:8 (3): 2385-2396
被引量:291
标识
DOI:10.1021/acscatal.7b03440
摘要
Cascade reactions catalyzed by multienzymatic systems have strongly moved into the focus of researchers in the field of biocatalysis because of their unique potential for the environmentally benign production of chemicals and materials. Inspired by Nature's ingenuity, considerable progress has been made in recent years to develop multistep reactions that combine the synthetic power of several enzymes in one pot. In addition, the combination of this biocatalytic power with the potential of chemical reactions, man-made transition-metal catalysts, and metalloenzymes has even further widened the repertoire of possible catalyzed reaction schemes. In this Review, we describe recent developments with respect to major challenges and solutions in the field of multienzyme cascade reactions, covering recent concurrent and sequential approaches with three or more enzymes in linear sequence as well as chemo-enzymatic reactions that combine a chemical step with at least two different enzymes over the last six years.
科研通智能强力驱动
Strongly Powered by AbleSci AI