化学
Negishi偶联反应
钯
脱质子化
催化作用
立体专一性
锌酸盐
有机化学
叔醇
药物化学
组合化学
离子
锌
作者
Hu Zhang,Stephen L. Buchwald
摘要
We report a Pd-catalyzed stereospecific α-arylation of optically pure 2,3-epoxy-1,1,1-trifluoropropane (TFPO). This method allows for the direct and reliable preparation of optically pure 2-CF3-2-(hetero)aryloxiranes, which are precursors to many CF3-substituted tertiary alcohols. The use of continuous-flow methods has allowed the deprotonation of TFPO and subsequent zincation at higher temperature compared to that under traditional batch conditions.
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