MAPK/ERK通路
抗凋亡Ras信号级联
信号转导
激酶
蛋白激酶A
丝裂原活化蛋白激酶
MEK抑制剂
p38丝裂原活化蛋白激酶
磷酸化
MAPK级联
化学
PI3K/AKT/mTOR通路
作者
Jarrett T. Whelan,Sarah E. Hollis,Dong Seok Cha,Adam S. Asch,Myon-Hee Lee
摘要
The Ras-ERK/MAP (Mitogen-Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras-ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis. Although the regulation of the Ras-ERK/MAPK signaling pathway by post-translational modification has been well elucidated, post-transcriptional regulations of this pathway are beginning to emerge in invertebrates and this work is extended to humans. In this review, we describe the conserved regulation of Ras-ERK/MAPK signaling by RNA-binding proteins (PUF, KH-domain, HuR, and LARP) and microRNAs (let-7 family miRNAs) and important implications for human diseases including cancers. J. Cell. Physiol. 227: 1235–1241, 2012. © 2011 Wiley Periodicals, Inc.
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