恶性胸腔积液
免疫系统
趋化因子
白细胞介素22
医学
胸腔积液
癌症研究
A549电池
胸膜疾病
病理
免疫学
白细胞介素
细胞因子
肺癌
呼吸道疾病
肺
内科学
作者
Zhijian Ye,Qiong Zhou,Wen Yin,Mingli Yuan,Jing Wang,Xiang Fei,Jianchu Zhang,Jian‐Bao Xin,Xian‐Zhi Xiong,Huan‐Zhong Shi
出处
期刊:Cancer Letters
[Elsevier]
日期:2012-12-01
卷期号:326 (1): 23-32
被引量:60
标识
DOI:10.1016/j.canlet.2012.07.013
摘要
Th22 cells have been reported to be involved in human cancers. However, differentiation and immune regulation of Th22 cells in malignant pleural effusion (MPE) remain unknown. We noted that Th22 cell numbers were increased in MPE, and that IL-22 substantially promoted the proliferation and migratory activity of A549 cells. Moreover, IL-22 could strongly facilitate intercellular adhesion of A549 cells to pleural mesothelial cell monolayers. Our data revealed that the increase in Th22 cells in MPE was due to pleural cytokines and chemokines, and that Th22 exerted an important immune regulation on cancer cells in human pleural malignant environment.
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