赫斯1
Wnt信号通路
癌症干细胞
转移
生物
癌症研究
上皮-间质转换
干细胞
串扰
癌细胞
细胞生物学
癌症
信号转导
Notch信号通路
遗传学
光学
物理
作者
Zi-Hao Liu,Xiaomeng Dai,Bin Du
标识
DOI:10.1080/15384047.2015.1016662
摘要
Hes1 is one mammalian counterpart of the Hairy and Enhancer of split proteins that play a critical role in many physiological processes including cellular differentiation, cell cycle arrest, apoptosis and self-renewal ability. Recent studies have shown that Hes1 functions in the maintenance of cancer stem cells (CSCs), metastasis and antagonizing drug-induced apoptosis. Pathways that are involved in the up-regulation of Hes1 level canonically or non-canonically, such as the Hedgehog, Wnt and hypoxia pathways are frequently aberrant in cancer cells. Here, we summarize the recent data supporting the idea that Hes1 may have an important function in the maintenance of cancer stem cells self-renewal, cancer metastasis, and epithelial–mesenchymal transition (EMT) process induction, as well as chemotherapy resistance, and conclude with the possible mechanisms by which Hes1 functions have their effect, as well as their crosstalk with other carcinogenic signaling pathways.
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