已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Intravoxel Incoherent Motion Diffusion-weighted Imaging of Multiple Myeloma Lesions: Correlation with Whole-Body Dynamic Contrast Agent–enhanced MR Imaging

盒内非相干运动 医学 核医学 有效扩散系数 骨髓 磁共振成像 磁共振弥散成像 多发性骨髓瘤 动态对比度 秩相关 灌注 放射科 病理 内科学 机器学习 计算机科学
作者
Camille Bourillon,Alain Rahmouni,Chieh Lin,Karim Belhadj,Pauline Beaussart,Alexandre Vignaud,Pierre Zerbib,F. Pigneur,C.A. Cuénod,Hocine Bessalem,Madeleine Cavet,Amal Boutekadjirt,Corinne Haïoun,Alain Luciani
出处
期刊:Radiology [Radiological Society of North America]
卷期号:277 (3): 773-783 被引量:50
标识
DOI:10.1148/radiol.2015141728
摘要

To correlate intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters with the enhancement patterns of bone marrow and focal lesion obtained on whole-body (WB) dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) images in patients with stage-III multiple myeloma (MM) before and after systemic therapy.Twenty-seven patients with MM were retrospectively included in this institutional review board-approved study. Requirement for written informed consent was waived. All patients underwent WB DCE MR imaging before treatment and 18 patients underwent repeat MR imaging 3 months after treatment. A transverse IVIM DWI sequence with 10 b values (0, 10, 20, 30, 50, 80, 100, 200, 400, and 800 sec/mm(2)) was acquired within bone marrow and focal lesions. The IVIM parameters (perfusion fraction [f], molecular diffusion coefficient [D], and perfusion-related D [D*]) and apparent diffusion coefficient (ADC) were extracted for both focal lesions and bone marrow and correlated with focal lesions and maximal bone marrow enhancement (BMEmax) (Spearman correlation coefficient) at baseline and at follow-up (Wilcoxon signed-rank test).D and ADC values positively correlated with BMEmax (r = 0.7, P < .001; and r = 0.455, P = .0435, respectively). Patients with increased BMEmax showed significantly increased ADC and D within bone marrow versus patients who did not have increased BMEmax (ADC, 0.67 × 10(-3) mm(2)/sec vs 0.54 × 10(-3) mm(2)/sec, P = .03; D, 0.58 × 10(-3) mm(2)/sec vs 0.42 × 10(-3) mm(2)/sec, P < .001). Within focal lesions, f was the maximum in lesions that showed enhancement followed by washout. After treatment in good responders, the significant decrease in maximal enhancement value of focal lesions (baseline vs after treatment, 213.9% ± 78.7 [standard deviation] vs 131% ± 53.6, respectively; P < .001) was accompanied by a significant decrease in f (baseline vs after treatment, 11% ± 3.8 vs 5.8% ± 4.7, respectively; P < .001).Diffuse bone marrow involvement is associated with increased D. Hypervascular focal lesions with high maximal enhancement value of focal lesions also show high f value. Likewise, the decreased maximal enhancement value of focal lesions after treatment is accompanied by decreased f.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Georgechan发布了新的文献求助10
5秒前
8秒前
lascqy完成签到 ,获得积分10
8秒前
okko完成签到,获得积分10
8秒前
15秒前
养乐多敬你完成签到 ,获得积分10
18秒前
CC发布了新的文献求助10
19秒前
在水一方应助leonzhou采纳,获得10
24秒前
SYLH应助ceeray23采纳,获得20
24秒前
斯文的难破完成签到 ,获得积分10
29秒前
36秒前
leonzhou发布了新的文献求助10
40秒前
pojian完成签到,获得积分10
42秒前
有趣的银完成签到,获得积分10
48秒前
星辰大海应助科研通管家采纳,获得10
48秒前
充电宝应助科研通管家采纳,获得10
48秒前
科研通AI2S应助科研通管家采纳,获得10
48秒前
啵啵啵小太阳完成签到,获得积分10
56秒前
FashionBoy应助freshfire采纳,获得10
57秒前
可达鸭完成签到 ,获得积分10
59秒前
聪明静柏完成签到 ,获得积分10
1分钟前
Foxjker完成签到 ,获得积分10
1分钟前
1分钟前
SYLH应助ceeray23采纳,获得20
1分钟前
饭ff发布了新的文献求助10
1分钟前
1分钟前
1分钟前
1分钟前
CNS发布了新的文献求助10
1分钟前
freshfire发布了新的文献求助10
1分钟前
遥知马完成签到,获得积分10
1分钟前
饭ff完成签到,获得积分20
1分钟前
一颗滚石完成签到,获得积分10
1分钟前
YiXianCoA完成签到 ,获得积分10
1分钟前
可爱的函函应助干净涵梅采纳,获得10
1分钟前
科研通AI2S应助科研达人采纳,获得10
1分钟前
CNS完成签到,获得积分10
1分钟前
Angela完成签到,获得积分10
1分钟前
betyby完成签到 ,获得积分10
1分钟前
sudor123456完成签到,获得积分10
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990012
求助须知:如何正确求助?哪些是违规求助? 3532047
关于积分的说明 11256141
捐赠科研通 3270918
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216