化学
氢胺化
多米诺骨牌
催化作用
组合化学
芳基
冷凝
级联反应
药物化学
吡唑
立体化学
作者
Wan‐Chen Pan,Tuan‐Jie Li,Jian‐Quan Liu,Xiang-Shan Wang
摘要
A new AgOTf-catalyzed domino reaction of 2-alkynylbenzaldehyde and 4-amino-1-methyl-3-propyl-1H-pyrazole-5-carboxamide has been reported via a sequential condensation, cyclization, and acetylenic hydroamination process. The developed protocol provides an efficient and modular access to a range of new fused tetracyclic heterocycle 6-aryl-9-methyl-11-propyl pyrazolo[4′,3′:4,5]pyrimido[2,1-a]isoquinolin-8(9H)-ones with two new rings in good yields.
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