The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics
Anubama Rajan,Ashley Weaver,Gina M. Aloisio,Joseph Jelinski,Hannah L. Johnson,Susan Venable,Trevor McBride,Letisha Aideyan,Felipe-Andrés Piedra,Xunyan Ye,Ernestina Melicoff,Malli Rama Kanthi Yerramilli,Xi‐Lei Zeng,Michael A. Mancini,Fabio Stossi,Anthony W. Maresso,Shalaka A. Kotkar,Mary K. Estes,Sarah E. Blutt,Vasanthi Avadhanula,Pedro A. Piedra
出处
期刊:MBio [American Society for Microbiology] 日期:2022-02-15卷期号:13 (1)被引量:32
There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can serve as an