化学
糖基
反应性(心理学)
亲核细胞
糖复合物
糖基化
三氟甲基磺酸三甲基硅烷基酯
低聚糖
糖基供体
组合化学
三氟甲磺酸
有机化学
催化作用
立体化学
生物化学
医学
替代医学
病理
作者
; Javed,Ariza Khanam,Pintu Kumar Mandal
标识
DOI:10.1021/acs.joc.2c00404
摘要
Both glycoconjugates and oligosaccharides are important biomolecules having significant roles in several biological processes, and a new strategy for their synthesis is crucial. Here, we report a versatile N-iodosuccinimide/trimethylsilyl triflate (NIS/TMSOTf) promoted glycosidation approach with shelf-stable 3-phenyl-4-pentenoate glycosyl as a donor for the efficient synthesis of O/C-glycosides with free alcohols, silylated alcohols, and C-type nucleophile acceptors in good to excellent yields. The mild activation conditions and outstanding reactivity of phenyl substituted pentenoate donors analogous to 4-pentenoate glycosyl donors enhance their applicability to various one-pot strategies for the synthesis of oligosaccharides, such as single-catalyst one-pot and acceptor reactivity-controlled one-pot strategies.
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